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Total 26026 results found since Jan 2013.

Vascular targeted photodynamic therapy in low-risk prostate cancer. A literature review.
CONCLUSION: VTP appear to be a promising new approach in localized low-risk prostate cancer. PMID: 31266699 [PubMed - as supplied by publisher]
Source: Progres en Urologie - July 5, 2019 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

Focal Laser Ablation and Photodynamic Vascular Therapy with soluble TOOKAD® in the treatment of low risk prostate cancer.
This article reviews the preclinical and clinical development of these innovative ablative techniques in the field of focal therapy for low risk prostate cancer. PMID: 27416636 [PubMed - in process]
Source: Archivos Espanoles de Urologia - July 17, 2016 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

Focal Laser Ablation and Photodynamic Vascular Therapy with soluble TOOKAD ® in the treatment of low risk prostate cancer.
This article reviews the preclinical and clinical development of these innovative ablative techniques in the field of focal therapy for low risk prostate cancer. PMID: 27416636 [PubMed - in process]
Source: Archivos Espanoles de Urologia - July 22, 2016 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

Cryoablation, high-intensity focused ultrasound, irreversible electroporation, and vascular-targeted photodynamic therapy for prostate cancer: a systemic review and meta-analysis
AbstractCryoablation (CA), high-intensity focused ultrasound (HIFU), irreversible electroporation (IRE), and vascular-targeted photodynamic therapy (VTP) have been evaluated as novel strategies for selected patients with prostate cancer (PCa). We aim to determine the current status of literature regarding the clinical outcomes among these minimally invasive therapies. A systematic search of PubMed, EMBASE, and the Cochrane Library for all English literature published from January 2001 to December 2019 was conducted to identify studies evaluating outcomes of CA, HIFU, IRE or VTP on PCa. Proportionality with 95% confidence i...
Source: International Journal of Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Is Movember synonymous with moustaches or men's health? An examination of internet search activity for prostate and testicular cancer during the campaign
ConclusionWe concluded that the Movember campaign is consistently linked in the public consciousness with novelty facial hair and only weakly associated with an awareness of prostate and testicular cancers. Whilst the funding generated by the campaign should be commended, more could be done to link the campaign and moustaches to awareness of common male cancers.
Source: Irish Journal of Medical Science - December 13, 2019 Category: General Medicine Source Type: research

An automatic framework for evaluating the vascular permeability of bone metastases from prostate cancer
CONCLUSION: The proposed CBM framework can provide a fully automatic and reliable quantitative estimation of vascular permeability for bone metastases in prostate cancer patients. Key words: DCE-MRI, Prostate bone metastases, Pharmacokinetic parameters, Clustering-based Blind identification of Multichannel framework (CBM framework).PMID:34010811 | DOI:10.1088/1361-6560/ac02d3
Source: Physics in Medicine and Biology - May 19, 2021 Category: Physics Authors: Junjie Wu Yi Zhu Xiaodong Zhang Xiaoying Wang Jue Zhang Source Type: research

Abstract 1709: Quantification of biologically relevant vascular phenotypes in human prostate cancer: automated image analysis using hyperplexed immunofluorescence
Although anti-angiogenic therapy has emerged as a leading modality in treating human cancer, further improvements in the duration and frequency of clinical response of various human cancers remain important clinical needs. Maturity of the tumor vasculature has been identified as one of the major determinants of response of cancers to anti-angiogenic treatments. We have developed and optimized the application of a quantitative, high throughput, hyper-plexed, fluorescence imaging technology to refine our understanding of the complexity of vascular phenotypes in various human malignancies. The technology was used to quantify ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Sevinsky, C., Santamaria-Pang, A., Zhang, J., Lowes, C., Sangurdekar, D., Falcon, B., Li, Q., Pytowski, B., Benjamin, L., Graff, J., Ginty, F., Nasir, A., Uhlik, M. T. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract A46: A bone marrow vascular niche model to study the effects of a DNA Damage Secretory Program in promoting prostate cancer treatment resistance
Conclusions: These studies suggest that effectors derived from the bone marrow vascular niche are differentially regulated following DNA-damage. Subsequently, those factors may influence tumor cell proliferation and/or resistance to therapy, but may do so in a tumor cell-specific manner. Characterization of the DDSP from the vascular niche could potentially unravel mechanisms of treatment resistance and tumor progression.Citation Format: Christine Levesque, Xin Zhao, Cyrus M. Ghajar, Peter S. Nelson. A bone marrow vascular niche model to study the effects of a DNA Damage Secretory Program in promoting prostate cancer treat...
Source: Cancer Research - May 25, 2016 Category: Cancer & Oncology Authors: Levesque, C., Zhao, X., Ghajar, C. M., Nelson, P. S. Tags: Tumor Dormancy and Resistance Source Type: research

Abstract B19: Vascular normalization suppresses tumor progression and potentiates docetaxel chemotherapy in prostate cancer
Conclusions: SAC-1004 improves hypoxic tumor microenvironment and restores abnormal leak vasculature of tumor by restoring endothelial cell junction in prostate cancer. Vascular normalization induced tumor regression and docetaxel combination following vascular normalization sensitized prostate cancer to docetaxel treatment.Citation Format: You Hyun Kang, Hyun A Jin, Jun Hyeok Heo, Ki Hong Kim, Kyung Seok Han, Sung Joon Hong. Vascular normalization suppresses tumor progression and potentiates docetaxel chemotherapy in prostate cancer. [abstract]. In: Proceedings of the AACR Special Conference: Function of Tumor Microenviro...
Source: Cancer Research - July 27, 2016 Category: Cancer & Oncology Authors: Kang, Y. H., Jin, H. A., Heo, J. H., Kim, K. H., Han, K. S., Hong, S. J. Tags: Therapeutic Targeting Tumor Microenvironment Source Type: research

TRPS1 knockdown inhibits angiogenic vascular mimicry in human triple negative breast cancer cells
CONCLUSIONS: Based on our results, and in light of previous studies, we thus proposed that TRPS1 suppression negatively affects vascular mimicry possibly through reduced TRPS1-mediated transcriptional regulation of VM-related protein VEGF-A.PMID:34216368 | DOI:10.1007/s12094-021-02676-9
Source: Clinical Prostate Cancer - July 3, 2021 Category: Cancer & Oncology Authors: M Wu X Sun T Wang M Zhang P Li Source Type: research

Cancers, Vol. 14, Pages 6020: TNF Signaling Is Required for Castration-Induced Vascular Damage Preceding Prostate Cancer Regression
Kent L. Nastiuk The mainstay treatment for locally advanced, recurrent, or metastatic prostate cancer (PrCa) is androgen deprivation therapy (ADT). ADT causes prostate cancers to shrink in volume, or regress, by inducing epithelial tumor cell apoptosis. In normal, non-neoplastic murine prostate, androgen deprivation via castration induces prostate gland regression that is dependent on TNF signaling. In addition to this direct mechanism of action, castration has also been implicated in an indirect mechanism of prostate epithelial cell death, which has been described as vascular regression. The initiating event is endo...
Source: Cancers - December 7, 2022 Category: Cancer & Oncology Authors: John J. Krolewski Shalini Singh Kai Sha Neha Jaiswal Steven G. Turowski Chunliu Pan Laurie J. Rich Mukund Seshadri Kent L. Nastiuk Tags: Article Source Type: research

Hypothesis driven single nucleotide polymorphism search (HyDn-SNP-S).
Abstract The advent of complete-genome genotyping across phenotype cohorts has provided a rich source of information for bioinformaticians. However the search for SNPs from this data is generally performed on a study-by-study case without any specific hypothesis of the location for SNPs that are predictive for the phenotype. We have designed a method whereby very large SNP lists (several gigabytes in size), combining several genotyping studies at once, can be sorted and traced back to their ultimate consequence in protein structure. Given a working hypothesis, researchers are able to easily search whole genome gen...
Source: DNA Repair - July 4, 2013 Category: Genetics & Stem Cells Authors: Swett RJ, Elias A, Miller JA, Dyson GE, Andrés Cisneros G Tags: DNA Repair (Amst) Source Type: research

Upile T, Jerjes W, Radhi H, Al-Khawalde M, Kafas P, Nouraei S, Sudhoff H. Vascular mimicry in cultured head and neck tumour cell lines. Head Neck Oncol. 2011 Dec 23;3:55.
We present experimental evidence of vasculogenic mimicry in HNSCC cell lines and compare them with other tumours and a positive control vascular cell line. Materials and methods The cell lines used were HUVEC, HN 2a, 2b (primary and metastatic tongue base squamous carcinoma cell line), HCT116 (colonic carcinoma cell line) and DU145 (prostate carcinoma cell line). Pilot experiments were undertaken to assess growth of a bank of tumour cell lines on (growth factor reduced) matrigel (Sigma) with standard media (DMEM with 10% Fetal Calf Serum). A functional growth assay was performed by preparing the appropriate cell su...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research